বৃহস্পতিবার, ৩১ মে, ২০১২

Veterans lose confidence in finding jobs: survey

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

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Windows 7 Registry Repair Tool Download - IdeaMarketers.com











This generation is a generation who depend on computers to get jobs done. Most industries, if not all, have incorporated the use of such technologies to make their manufacturing, advertising and operations more efficient and effective. Almost every person on the planet depends on a smooth running PC to get a job done. Most PC's run on a Windows 7 operating system. However, just like any operating system, it is prone to have errors once in a while. Getting a top quality registry cleaner software can help speed up your PC quickly.

The error might occur when the users don't pay attention to the cautions about things that they do with the computer such as when they install certain programs. This issue makes people all over the world discuss about this operating system. Even though Windows 7 is introduced with its excellent quality, people are surprised when error happens in Windows 7. For some computer users, they will install more programs to enhance their computer performance. On the other hand, they can have technician to fix the computer. These options require cost. The most efficient way is cleaning up the system's registry using the registry cleaner software.

Think of your registry as your computer's command post or brain. With a new computer everything is running smoothly but as you install and uninstall some programs your command post starts getting cluttered. Various programs you install will modify your registry. Once you decide to uninstall some of these programs, the modifications made to your registry won't always be modified back making your computer deal with the data left behind by the uninstalled program.

When the registry is cleaned up, it will remove adware which possibly hides in the registry. It becomes one of the reasons why computer users clean the registry. Adware causes more clutter. As the result, the computer will be difficult to read amount of data. The computer performance will be poor. Cleaning the registry with a Windows 7 Registry Repair Tool will be the best way to bring the best performance of the computer back.

This is one of the reasons why Windows 7 has added a registry editor program for people that understand the intricate system that the operating system runs in. For those of you who are not proficient with technical computer processes, you can always use registry cleaner software. All you have to do is to download and install registry cleaner software from the internet. There are many advantages to using registry cleaners. Registry cleaners are easy to come by and are usually free of charge.

It is very easy to find one that is compatible with your Windows 7 PC or laptop. You don't have to change anything with the registry editor and run a chance of disrupting anything important. This would minimize the problems and errors that your computer runs into. This in the long run would improve your computer's overall performance. If you want to further improve your computer then picking up a PC health advisor would help deal with your endeavors.

It is not difficult to find compatible registry cleaner software for Windows 7 in the internet. When installing this software, changing something in registry editor is not required. One of the benefits is that the problems in the computer will be minimized. On the other side, the performance of the computer will be enhanced. For more improvement for the computer performance, PC health advisor is needed. It has been reported that registry cleaner software doesn't only speed up the computer with windows 7 as its operating system, but improve the performance of the computer as well. In a nutshell, this software will be an important utility tool to make the performance of the computer better. I personally managed to clean up my computer by downloading high quality registry cleaner software and would highly recommend it.

Keywords: windows 7 registry repair tool, windows 7 registry repair,registry repair tool,registry repair

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Structured Settlement Lump Sum Cash for structured settlement or ...

If you are getting monthly annuity payments or structured settlement payments, you can exchange those for a single lump sum of cash. There are many good reasons to take advantage of structured settlement loans for immediate needs, rather than wait for cash in installments.

What is a Structured Settlement?

Structured settlement loans or payments are financial or insurance payments arranged by the judicial system as a result of a personal injury claim, wrongful death, auto accident, medical malpractice, or other circumstance. Often, structured settlement loans are distributed in low monthly amounts, spreading the money owed over a long period. This arrangement is known as fixed annuity payments, meaning the same amount of money distributed at evenly spaced intervals.

There are legal financing companies that will pay part or all of your structured settlement loans or annuity payments in exchange for a lump sum. Getting lump sum cash for structured settlement instead of installment annuity payments gives you the freedom to access your money immediately.

Exchange Annuity Payments for Lump Sum

Low annuity payments can make it difficult to make large purchases, such as putting a down payment on a house, paying off debts, covering college or medical expenses, or buying a car for transport. A structured settlement gives you the opportunity to sell some or all of your structured settlement loans for increased monthly payments or a lump sum.

A structured settlement will allow you to get cash against future annuity payments for big expenditures or investments, such as starting your own business. Cash for structured settlement payments means you will still receive future annuity payments but you will have to pay back the loan just like any other debt.

Cash for structured settlement can help give you a fresh start financially, eliminating debt and catching up on bills. Whatever the reason you want to take advantage of a structured settlement, there are things you should consider with cash for a structured settlement.

The legal financing company you choose should provide free, no-obligation quotes so that you can compare offers for a structured settlement. These financing companies should also be willing to manage the majority of the paperwork to make the process easy and convenient. The goal should be to get the cash for annuity payments as quickly as possible.

These financing companies may also suggest you to other forms of lump sum cash sources, such as state, county, and city pensions, military and government pensions, corporate pensions, and more. If you have structured settlements, you can rest assured that there are many options you can take for financial opportunities.

For more information, visit http://www.lumpsum-settlement.com/

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Tuesday Night Acoustic: Maneli Jamal - Movement III - on the Run (Little green footballs)

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Flipboard beta coming to all Android devices soon, hopes to handle resolution variety with poise

Flipboard on Android

Eagle-eyed readers might remember that Flipboard's long-awaited port to Android started with a fair amount of confusion; it showed up (seemingly at random) on Samsung's Galaxy S III, but soon after, we learned that it would only be available for that very phone over on the Android side of things. Recently, we uncovered the story of why, and what the company's planning for the future. Put simply, that "device diversity" that keeps developers on their toes is at the forefront of the issue here. For those unaware, Flipboard is quite the polished app over on iOS, and the outfit didn't want its product to offer a subpar experience on competing platforms. In order to gain a better grip on the app's appearance in the land of mobile desserts, it teamed up with Samsung to focus on a single screen, and a single screen resolution. Naturally, it's expecting a huge amount of GSIII shipments, so that's certainly not a bad device to start on. But in the effort of understanding Flipboard's future on Android, it's important to note that whole "start" phrase.

Turns out, the company's eerily close to having a build ready for the rest of the Android smartphone universe. But, smartly, it's planning to release it to a small subset of users with a clear 'beta' label. The idea here is to offer it up to savvy Android users who understand the art of sideloading an APK, giving them the tools to submit bug reports and help polish up Flipboard on the many, many variations of devices out there. Truth be told, we wish more app makers would give this approach a try. Tossing that 'beta' label on there keeps expectations in check, and allowing early adopters to chime in with bugs enables the final product to be that much more stable across a wide gamut of screen resolutions. We weren't able to nail down a specific launch date, but Android aficionados hoping to get a few flips in shouldn't have to wait too many more months before that beta offering is made public. In the meanwhile, there's always the renegade method -- but of course, we'd caution that you proceed at your own risk.

Flipboard beta coming to all Android devices soon, hopes to handle resolution variety with poise originally appeared on Engadget on Wed, 30 May 2012 08:22:00 EDT. Please see our terms for use of feeds.

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Video: Rep. Lewis: Register and vote like you?ve never voted before

Salmonella by mail? Hatchery sparks outbreak

It took eight years and multiple tests, trace-backs and interviews with sick owners of fuzzy chicks, but federal health officials say they?ve finally clamped down on an outbreak of salmonella infections traced to live, mail-order poultry.

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বুধবার, ৩০ মে, ২০১২

Toronto's Tallest Residential Condo Tower-50 Bloor West ? Toronto ...

Posted by: torontocondo | May 30, 2012

Toronto?s Tallest Residential Condo Tower-50 Bloor?West

Condos Yonge Bloor Toronto

Condos Yonge Bloor Toronto

Toronto Bloor West Condo

A new Toronto Condominium project at 50 Bloor St. West will be the tallest Toronto Condo tower and the tallest in Canada as well.

This exciting new?project in an ideal location at the crossroads of two Subway lines will add to Bloor Streets premier shopping and dining destination.

This?Bloor/Yonge St.? area?has seen over 30 new Toronto?Condo developments in just over 10 years.

Here are just a few Yonge/Bloor and Bay/Bloor Condos:

  • Casa Condos
  • The Uptown Condos
  • Crystal Blu Condos
  • Milan Condos
  • Couture Condos
  • U Condos
  • The Yorkville Condos
  • Florian
  • One Bedford Condos
  • Four Seasons Condos

Here are current Yonge/Bloor St. Condos for sale or rent!

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Posted in Toronto Condo | Tags: Bay Bloor Condos, Bloor St. West, Bloor Yorkville Condos, Tallest Canada Condo, Tallest Toronto Condos, Toronto Bloor West Condo, Toronto Condo, Toronto Condo Blog, Toronto Condo developments, Toronto Condominium, Yonge Bloor Condos


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Agriculture forum: A big year for local food in schools ? Business ...

Another example of MLUI leading the way in Northern Michigan. ?Great job Diane!? ?With asparagus spears and rhubarb stalks poking up through the ground, many schools throughout northwest Lower Michigan are capping off a big year of celebrating and serving locally grown food.?

See on record-eagle.com

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Look for Less: Kourtney Kardashian?s Street Style

While stepping out to celebrate Mother's Day in Santa Monica, Calif on May 13, the mom-to-be looked oh-so sophisticated in a head to toe black and white ensemble.

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মঙ্গলবার, ২৯ মে, ২০১২

Impression on the Homebrew wii within the Nintendo wii gaming ...

For quite some time now it is commonplace for those running a Nintendo Wii to have what?s become termed as a visit this site. Without getting too technical, this basically allows web-sites the Nintendo wii gaming console to reach all of the hardware functions on the device ? and also bypass any copy protection.

That will put that in layman?s terms, when you use a homebrew wii you don?t worry about whether a game is original, and actually it can save you games directly on to your Wii or produce a copy ones and run them as and ways in which the thing is that fit. Several games have even been designed tailored for homebrew wii machines ? and thus many individuals nowadays install the homebrew wii only to obtain these games.

Properly boil everything down, exactly what the homebrew wii installation it?s essentially doing is ?breaking into? the framework on the Nintendo software. Naturally, which is not an element that Nintendo ?intended? and so it is capable of having a direct effect though it has to be declared a lot of the latest installations are really fairly stable.

Early versions from the homebrew wii had some risk of corrupting the computer and perhaps even ?bricking? it. Occasionally some issues with network connectivity along with the remote sensor would be also reported.

These types of issues happen to be resolved and for that reason unless you?re utilizing an earliest pens version of your homebrew wii installation you won?t worry about them.

That said, there exists a very important factor that could actually get involved towards you, which is the Nintendo wii gaming console updates. Obviously, Nintendo doesn?t really offer the ?homebrew Wii? installations and for that reason when you?ve got a Nintendo Wii that is certainly homebrewed then you most likely are not able to install any official updates and even if you it may eliminate the homebrew wii functions.

Sometimes when an update is released it?s impossible to setup the homebrewwii.com.au for quit some time if this update happens to fix a lot of the ?exploits? which are utilized to install the homebrew wii. So should you be set on updating, it becomes a good idea to verify that the version that you?re updating to can in fact be ?homebrewed?.

Essentially, the homebrew wii definitely does have a positive change to the Wii system ? but a majority of of that impact is actually comparatively minor and might be worked around. All you should do is make certain that you?re using among the numerous legitimate installers available and you ought to have no issues whatsoever. Actually, you will be in a position to enjoy the homebrew channel sooner rather than later.

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Shay Williams Garrett Roll-outs Non-Profit Business Within A good ...

Altlanta ga, Ga instruction Shay Williams-Garrett, additionally recognized because ?Shay Your own Day Diva? in order to the girl followers, is actually the author, loudspeaker as well as romantic relationship trainer that offers released the non-profit business: DIVA KNOWLEDGE (Females, Influenced in order to, Effectively, Day, Just with regard to, Relationship) within a good work in order to assist reduce the actual staggering solitary mother or father price which proceeds in order to develop within The united states. The actual objective associated with DIVA KNOWLEDGE is actually in order to assist avoid as well as finish solitary raising a child as well as teenager being pregnant through teaching as well as motivating females in order to create sensible romantic relationship options as well as in order to stay open up in order to brand new as well as healthful human relationships which eventually guide in order to relationship. The actual business expectations in order to motivate local community advancement through reducing fatherless houses.

Shay Garrett that had been as soon as the solitary mom their self states, ?Being the solitary mom is actually the actual toughest work upon planet. In order to appear in your own kid that offers in order to develop upward along with away viewing very first hands exactly what the nucleus family members seems such as is actually cardiovascular wrenching. This is actually additionally unpleasant in order to understand which your own child or even child might develop upward without having actually viewing their own mom getting cherished as well as handled correct through the great guy therefore which they will on their own will certainly become outfitted in order to replicate the actual exact same point. inches

Even though numerous possess already been elevated effectively inside solitary mother or father houses, Shay?s issues tend to be typical amongst numerous solitary moms and dads. Within inclusion, generally there tend to be the great deal associated with straight down edges in order to solitary raising a child as well as staying solitary which impact the actual whole nation. In accordance in order to the actual Agency associated with the actual Census, 63% associated with youngsters suicides, 71% associated with almost all higher college dropouts, as well as 70% associated with juveniles within condition operated establishments arrive through fatherless houses. Within 1996, younger kids residing along with single moms had been 5 occasions because probably in order to become bad as well as 10 occasions because probably in order to become very bad. Within inclusion, 72% associated with young murderers increased upward without having dads, as well as 60% associated with Many rapists increased upward the actual exact same method. Final however not really minimum, the actual percentage associated with solitary mother or father families within the local community forecasts the price associated with chaotic criminal offense as well as theft, however the actual community?s low income degree really does not really. (Resource: M. The. Cruz as well as Gary the gadget guy. L. Jarjoura, ?Social Framework as well as Legal Victimization, inches)

Shay Williams-Garrett offers assisted numerous females about the actual world via the girl on the internet training as well as courses in DIVA College discover really like as well as bring in much better high quality human relationships however might such as in order to companion along with some other females focused businesses as well as business sponsors within a good work in order to assist much more females within the girl personal back again backyard.

DIVA KNOWLEDGE expectations in order to bring up cash therefore in order to attract females that wish in order to get on the internet courses in DIVA College however are not able to pay for this or even that tend to be specific through their own local community business in order to become in higher danger with regard to bad romantic relationship options which eventually guide in order to additional repair a pregnancy or even solitary motherhood. DIVA KNOWLEDGE additionally appears ahead in order to joining up along with females businesses which will certainly suggest or even actually create obligatory with regard to their own people or even customers in order to take part within the actual academic romantic relationship programs in DIVA College.

Beginning Aug 2010, Shay Williams-Garrett as well as the girl group will certainly carry out on the internet as well as away collection courses associated with DIVA College tips, 102 as well as 103. The girl will certainly become talking in order to, teaching as well as coaching teenager young ladies, solitary moms as well as females that just wish in order to prevent creating bad romantic relationship options which may possibly guide in order to all of them getting the solitary mother or father. Within these types of programs the girl will certainly instruct solitary females along with or even without having kids regarding really like, online dating as well as human relationships as well as exactly how in order to bring in the actual guy associated with their own desires within much less compared to 35 times. This particular very first begins along with recovery previous injuries as well as busting straight down perception obstacles which perhaps position within their own method associated with bringing in the healthful really like encounter.

Shay really does not really guarantee the girl college students will certainly discover really like within 35 times, because the issue associated with reality the girl attempts this. The girl guarantees which the girl may assist any kind of lady that is actually prepared in order to bring in the great guy that may possibly become ?The One? within much less compared to 35 times. With regard to a few college students the actual 30-day procedure in order to bringing in the excellent guy are not able to start till the actual psychological problems tend to be recovered. DIVA College courses will certainly acknowledge among 30-50 females for each course as well as Shay Williams-Garrett will certainly fulfill along with all of them on the internet, as soon as the 7 days with regard to 7 several weeks with regard to a good hours every course. The girl will certainly additionally journey in order to services via away the actual nation in order to carry out weekend break lengthy workshops which reduce the actual on the internet course in to a few times. These types of online courses will certainly become info loaded, packed along with actions as well as tend to be certain in order to modify the actual life associated with females almost all about the actual nation.

DIVA KNOWLEDGE will certainly spend with regard to every lady that qualifies in order to get totally free sign up in order to the actual DIVA College programs, monthly subscriptions with regard to 3 on the internet online dating websites as well as a few childcare costs, a few females will certainly actually be eligible in order to get upon heading training through Shay Williams-Garrett individually.

Shay Williams-Garrett feels which because the actual improve associated with fatherless houses adversely impacts the actual whole nation, all of us almost all ought to perform our own component within assisting in order to enhance this particular scenario. Business sponsors tend to be motivated in order to check out the actual web site in www.divawisdom.com in order to create the monetary gift associated with in minimum $1500 these days or even market DIVA KNOWLEDGE through their own mag, radio stations display or even organization web site. Daily males as well as females tend to be motivated in order to donate in minimum $5. Almost all sponsors will certainly get reputation with regard to their own sponsorship. Shay request which the actual nation sign up for the girl within altering the actual globe through removing solitary the children 1 lady in the period.

http://www.shaywilliamsgarrett.com.

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Genetic Cause of Stunted Growth in Babies Discovered

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Loans For The Military

This assistance is not limited to specific branches of service. Any active or retired service man or woman will be considered for a loan for the military providing they meet the criteria involved in qualifying for approval. Some of the criteria might include the length of service remaining in a service man or woman's enlistment. A few companies that offer loans for the military require that the applicant have at least six months or so remaining in their term of service after the date of their last repayment.

Military service men and women do have certain advantages when it comes to loans. Interest rates are usually a bit lower than the current prime interest rates. However, a two or three percent margin may be added depending on the applicant's credit history. Approval on loans for the military is typically quick and easy because of the privileged nature of the status. A loan for the military to purchase real estate will have a variety of choices in regard to the term and type of funding, just as real estate loans do. This funding will offer either fixed rate or the adjustable rate mortgage. Most service men and women will qualify for zero percent down financing.

"But my God shall supply all your need according to his riches in glory by Christ Jesus" (Philippians 4:19). Service men and women can use assistance to make home improvements or to take that well-deserved vacation. Loans for the military can also be used to make repairs on vehicles, such as cars, boats, or motorcycles. The lending institution is not concerned with how the money is used as long as it is paid back on time. Repayment of a loan for the military is often made very effortless on the borrower's part by using direct debit from the borrowers bank account. This ensures that the payment will be made on time and not forgotten. Penalties can often be the result of late payments.

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Prep Soccer Popularity in U.S.

Back during the crazy period of my mid to late 20's, I spent some time in Brazil. I had visions of importing motorcycle helmets from Taiwan where I was living before I digress. One of my favorite things about the daily "grind" of life in Sao Paulo was nap I would take (you know, to make my adoptive family feel more at ease) shortly after lunch. I remember one day lying there in mid afternoon app bliss with the window open to the sounds of city just beyond the wall. It wasn't terribly hot and the window allowed airflow as the weather changed every 15 minutes. All of a sudden, I heard a giant roar across the city. I shot up in my bed with that panicky fight of flight feeling although I'm not sure what the fight would amount to. The roar seemed to come from every building all at one time and also filtered from my friends in the other room. I stumbled out of the bedroom to figure out what the Brazilian equivalent of an earthquake is. It's turns that there was a World Cup Soccer game going on and Brazil had just scored a winning goal against it's rival...might have been Argentina or Germany. This was around 1995. I stood there stunned to realize that a soccer goal was the the source for what seemed an end of earth even from my window. Soccer was serious stuff in Sao Paulo. The fact that this was surprising to me can only mean one thing...I was from the U.S.

So what gives? Why isn't soccer as popular in the U.S. as in pretty much any other place in the world. In fact, soccer is the most popular sport in the world. It's only in the U.S. that it doesn't translate yet. The strange thing is that it starts off so strong. Go out on any fall Saturday and take a look at the local middle school sports fields. They're likely to be packed with kids running around brightly covered AYSO soccer jerseys. Just dozens of them. It's one of the most organized and popular youth sports you'll find in the U.S. Where does it drop off and why?


At PrepSportFantasy.com, we love all high school sports and prep soccer is right up there. If there's a ball, we're all in. So what's our un-informed and unscientific take on soccer's relative position when compared to other countries. The only thing we can think of is American football. If you look at other sports, others are very popular in different countries as well. Baseball is huge in some countries and basketball is one of the fastest growing in popularity that you'll find. Only American football doesn't have a foothold in almost every other country. In fact, it's one of the least international sports you'll find. It really is unique to the U.S. Why does this matter? Ask any 8th grader. Early middle school is about the time that most prospective high school athletes make decisions on which sports to focus on. If you're a really good athlete on the soccer field, the skills translate well to American football and all you have to do is go to a friday night high school football game and take a look around to know which team you want to be on. Americans love their football and soccer might be the zero-sum game victim of this love. Don't rule soccer out yet though, it's steadily increasing in popularity. Maybe one day, we'll hear the roar across Los Angeles or New York from a World Cup goal.

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Video: Best viral video of week: Bat mitzvah dance

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Discovery expected to shift research direction in lupus and asthma

ScienceDaily (May 27, 2012) ? Newfound details of the immune system suggest a role for never-before-considered drug classes in the treatment of allergic and autoimmune diseases, according to a University of Alabama at Birmingham study published online May 27 in Nature Immunology.

The results advance the current understanding of the way the body's initial, vague reaction to any invading organism expands into a precise and massive counterattack. That expansion starts when a dendritic cell "swallows" a piece of any invader encountered, ferries it to the nearest lymph node and presents it there for notice by lymphocytes, the workhorse cells of the immune system.

According to the current model, dendritic cells first must encounter T lymphocytes in the paracortex, or T cell zone, within the node. Only there will the interaction enable lymphocytes to expand into an army of clones primed to attack the invader.

To the research team's great surprise, the data showed that, although immune response works this way during viral flu infections, it is not always the case. When the body is infested with parasitic worms, for instance, dendritic cells link with T cells near B lymphocytes, under the control of B cell-related signals and outside the T cell zone.

"Considering that diseases from asthma to lupus can occur because the system mistakenly ramps up the same types of T cell responses it normally uses against worms, our finding that B lymphocytes control the T cell/dendritic cell interactions that trigger such responses has important, practical implications," said Frances Lund, Ph.D., chair of the UAB School of Medicine's Department of Microbiology and corresponding author. "The field now has cause to look at several experimental and existing drugs known to interrupt B cell signals as potential treatments for diseases driven by T cells."

Study details

Before joining UAB in March 2012, Lund worked alongside Tim Mosmann, Ph.D., at the University of Rochester Medical Center. In 1986 Mosmann advanced his groundbreaking theory on the way the immune system decides which sets of immune cells are most effective against different invader types. According to his Th1/Th2 model, Th1 T helper cells were best against viruses because they helped invaded human cells self-destruct before viruses could turn them into virus factories. Th2 helper T cells were best against parasites because they helped the B cells mass produce antibodies that glommed onto and removed worms from the spaces between cells.

The current study found that B cells, as part of the Th2 response to worms, start pumping out a protein called lymphotoxin, which in turn signals nearby stromal cells to produce more of the chemokine CXCL13.

B cells are able to gather in B cell areas of lymph nodes in the first place because they express CXCR5 receptor proteins that sense and move toward higher concentrations of CXCL13. The team discovered that a set of dendritic cells also begins expressing CXCR5 during a worm infection.

With B cells and activated dendritic cells gathered near B cells, T helper cells next must join the party if the immune response is to expand. While T cells dump into lymph nodes at many points, only those that happen to enter near B cells, and to bump into CXCR5-expressing dendritic cells, drive the response to worms forward, according to the authors.

The authors also believe such interactions trap T cells near the B cell area and that proximity determines the kind of cells they becomes next. Those receiving the strongest signals become the T helper follicular cells that B cells must partner with to produce antibodies specific to the current pathogen. Those getting weaker signals become Th2 effectors that travel back to the infection site to cause the histamine release and intestinal muscle contractions that help to expel worms.

Though vital to effective immune responses to worms, T helper follicular cells and Th2 cells have a dark side. For example, T helper follicular cells in some cases inappropriately help B cells produce high affinity "auto" antibodies that recognize the body's own cells as foreign and can destroy the kidneys of lupus patients and the joints of patients with rheumatoid arthritis.

In other cases, Th2 cells respond to allergens in the lung like house dust mites because the mites look like worms to the immune system and the confused Th2 cells respond to the allergen as they would to a worm. This mistaken recognition causes histamine release and bronchoconstriction in the lungs, two of the major clinical symptoms of asthma.

"We know of experimental biologics that interrupt the ability of B cells to give off lymphotoxin and prevent the development of helper Th2 cells and T helper follicular cells," Lund said. "Could such antibody-based treatments be useful against some autoimmune diseases and asthma? We think so, but time and further studies will tell."

Along with Lund, Troy Randall, Ph.D., the Claude Bennett Scholar in the UAB Department of Medicine's Division of Clinical Immunology and Rheumatology, and UAB post-docs Beatriz Le?n, Ph.D., and Andr? Ballesteros-Tato, Ph.D., made major contributions to the work. Also making important contributions were Jeffrey Browning at Biogen Idec and Robert Dunn at the Pfizer Centers for Therapeutic Innovation (formerly at Biogen Idec). The study was supported by the National Institute of Allergy and Infectious Diseases.

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Story Source:

The above story is reprinted from materials provided by University of Alabama at Birmingham, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Beatriz Le?n, Andr? Ballesteros-Tato, Jeffrey L Browning, Robert Dunn, Troy D Randall, Frances E Lund. Regulation of TH2 development by CXCR5 dendritic cells and lymphotoxin-expressing B cells. Nature Immunology, 2012; DOI: 10.1038/ni.2309

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Obama honors fallen troops at Arlington Cemetery

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সোমবার, ২৮ মে, ২০১২

Fund managers look for tax cuts | Vietnam Business News

Fund managers are lobbying regulators for tax cuts.

Pham Dinh Thi, deputy director of the Ministry of Finance?s Tax Policy Department, said corporate income tax (CIT) reductions for the fund management industry should be considered. ?Commercial banks, the main capital mobilisation channel of Vietnam?s economy, are now subject to a CIT rate of 25 per cent. Therefore, we must study and discuss possibilities to lower taxes for fund management companies,? said Thi.

The statement was delivered at a Hanoi-based securities business tax policy conference last week where several fund managers demanded a CIT rate lower than the common 25 per cent tax rate, to stimulate the young fund management industry.

?Stock markets are usually the main capital mobilisation channel attracting 80 per cent of a society?s mobilisation capital. But that?s not the case in Vietnam where banks are the main channel for short and medium-term funds,? he said. State Securities Commission (SSC) Fund Management Department head Pham Thanh Long said a tax policy review was necessary. ?It is necessary to make tax policy changes to encourage investors to deposit in long-term investment funds, instead of speculative funds,? he said.

Long considered the new fund groups, including real estate investment funds, especially real estate investment trust (REIT) funds which mainly invest in housing and leasing, exchange traded funds (ETFs) and securities investment companies, as the new pillars of the investment fund industry, together with current pillars such as state-managed social insurance funds.

Thi said he would propose a ?specific circular? to guide securities businesses. ?It?s a rare case to have a specific circular to guide one sector. But with so many tax policy problems outstanding in the securities sector, I think a specific circular is essential.?

A representative of Vietnam Fund Management Club said according to this club?s calculations, fund investors always had to bear 5 per cent losses compared with other stock market investors due to tax policies and called for a tax reduction for this industry.

Bui Thu Thuy, head for HSBC?s Securities Services, said: ?For our international customers, Vietnam is just one of many venues for their portfolio investment and tax policy is one of many important factors for them to compare and consider investments.? ? VIR

Tags: vietnam stock, Vietnam stock market, VNindex

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HOT COUGAR ACTION: Baseball Wraps Up Its Season Today

The WSU baseball team will wrap up their season with a final game against Washington today. The Cougars lost the first two games of the series. Today's game is scheduled for 1 p.m. in Seattle. If you are in the area or are planning on attending, you can meet up with Kyle and Jeff and a few other CougCenterers.

Sticking with baseball, Mike Leach was in Seattle yesterday and took in a Mariners game. Before the game, Leach was down on the field for batting practice. As you can see, he spent some time talking with Eric Wedge and Jack Zduriencik. Leach is always curious so I wonder if he asked Zduriencik why he made a certain trade. If he did, maybe it went a little like this.

Seinfeld: Jay Buhner (via Ortmeyer41)

Star-divide

Baseball

Cougars Drop Second-Straight to Huskies - The Washington State University Official Athletic Site
SEATTLE - Collin Slaybaugh collected three hits and two RBI in a losing effort as Washington defeated Washington State 5-2 for the second-straight day in Pac-12 Conference baseball.

Football

M's notes: More on the closer change | Mariners Blog | The Seattle Times
The Mariners welcomed new Washington State football coach Mike Leach and his teenage son Cody. Wedge met Leach and general manager Jack Zduriencik chatted extensively with Leach around the batting cage.

Newest WSU football coach doesn?t skip a beat
Sears, 44, a Pullman, Wash., native who played wide receiver at his hometown school of Washington State and was the co-defensive coordinator there the past three seasons, never seems to be far from the initials W-S-U.

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Sof? y mesa de centro, dos en uno

Para votar este post con?ctate con Facebook Connect

sofa con mesa incorporada

Un d?a m?s seguimos con el eterno debate de la mesa de centro de la que yo soy firme defensora, as? que en mi empe?o por conseguir que no desaparezca de los salones de vuestras casas, siempre os muestro las posibles soluciones para no prescindir de ella pero que estorbe lo menos posible, sobre todo en el caso de salones peque?os.

En esta ocasi?n me he encontrado este sof? que es ideal para un peque?o sal?n de un apartamento t?pico de hoy en d?a, como veis el sof? tiene algunos m?dulos, zonas r?gidas y otras acolchadas, da la impresi?n de que algunas de estas piezas son extraibles y as? es. La mesa de centro est? incorporada en el sof? y solo tenemos que empujarla hacia delante para usarla con comodidad.

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Y no solo eso, sino que al mismo tiempo que extraemos la mesa de centro, tambi?n conseguimos dos peque?os cojines de suelo ideales como asientos auxiliares. As? que de un sof? biplaza pasamos a un conjunto completo de sala de estar para varias personas, podemos colocar el sof? de un modo u otro con la mesa recogida o no, en funci?n de las necesidades de cada momento.

V?a | Hometone
M?s informaci?n | Matthew Pauk
En Decoesfera | Un sof? con mesa auxiliar incorporada

Correo enviado con ?xito

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Inhabitat's Week in Green: Jake Dyson's lamp, wooden light bulbs and weed-killing lasers

Each week our friends at Inhabitat recap the week's most interesting green developments and clean tech news for us -- it's the Week in Green.

wooden light bulb

This week Inhabitat has been reporting live from New York Design Week, where we've witnessed countless innovative green designs from around the world. To kick things off, we were pretty impressed with this desk lamp designed by Jake Dyson (son of the vacuum god) that extends the life of its LED bulbs by a whopping 37 years. Also in the category of "bright shiny things we love" is QisDesign's Aurelia lamp, which bears a striking resemblance to a glowing jellyfish. We were also dazzled by UM Project's collection of retro, robot-inspired lamps, Light & Contrast's cute LED flower lights, and we were absolutely floored by Alessandro Jordão's larger-than-life LEGO chair. Can't get enough of NY Design Week? Check out all of our favorite green designs from this year's shows.

Continuing with the topic of innovative green lighting technology, artist Ryosuke Fukusada has created the impossible: a glowing wooden light bulb. Confused? The light was created using a technique called Rokuro, and it consists of an LED light bulb wrapped with a very thin layer of wood. When the bulb is turned on, it illuminates the grain of the wood. As Fukusada's creation demonstrates, LED lighting technology has taken some incredible strides recently, and we took some time to round-up 24 of our all-time favorite green lamps that look great with LED bulbs.

Continue reading Inhabitat's Week in Green: Jake Dyson's lamp, wooden light bulbs and weed-killing lasers

Inhabitat's Week in Green: Jake Dyson's lamp, wooden light bulbs and weed-killing lasers originally appeared on Engadget on Sun, 27 May 2012 20:28:00 EDT. Please see our terms for use of feeds.

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Obama's Truth Team Being Brainwashed

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রবিবার, ২৭ মে, ২০১২

Astronauts to Spend Memorial Day Unpacking Private Space Capsule

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