Scientists at the Johns Hopkins Kimmel Cancer Center have combined the ability to detect cancer DNA in the blood with genome sequencing technology in a test that could be used to screen for cancers, monitor cancer patients for recurrence and find residual cancer left after surgery.
"This approach uses the power of genome sequencing to detect circulating tumor DNA in the blood, providing a sensitive method that can be used to detect and monitor cancers," says Victor Velculescu, M.D., Ph.D., professor of oncology and co-director of the Cancer Biology Program at Johns Hopkins.
A reportdescribing the new approach appears in the Nov. 28 issue of Science Translational Medicine. To develop the test, the scientists took blood samples from late-stage colorectal and breast cancer patients and healthy individuals and looked for DNA that had been shed into the blood.
The investigators applied whole-genome sequencing technology to DNA found in blood samples, allowing them to compare sequences from cancer patients with those from healthy people. The scientists then looked for telltale signs of cancer in the DNA: dramatic rearrangements of the chromosomes or changes in chromosome number that occur only in cancer cells.
No signs of cancer-specific chromosome changes were found in the blood of healthy individuals, but the investigators found various cancer-specific alterations in the blood of all seven patients with colon cancer and three patients with breast cancer. Using specialized bioinformatic approaches, they were able to detect these alterations in a small fraction of the millions of DNA sequences contained in the blood sample.
"This is proof of the principle that genome sequencing to identify chromosomal alterations may be a helpful tool in detecting cancer DNA directly in the blood and, potentially, other body fluids," says Rebecca Leary, a postdoctoral fellow at Johns Hopkins. "But larger clinical trials will be needed to determine the best applications of this approach."
The investigators note that there may be less circulating DNA in early stage cancers, and, thus, these would be more challenging to detect without more extensive sequencing. As sequencing costs decrease, the investigators expect that detecting earlier-stage cancers may become more feasible.
Velculescu says that additional research will focus on determining how the new test could help doctors make decisions on treating patients. For example, the blood test could identify certain chromosomal changes that guide physicians to prescribe certain anti-cancer drugs or decide patient enrollment in clinical trials for drugs that target specific gene defects. Currently, physicians use cellular material biopsied from the original tumor to make these decisions, but tumor material can often be inaccessible or unavailable.
The Johns Hopkins study builds on the team's earlier work using genomic sequencing of DNA in the blood to find rearrangements of chromosomes. The previous work required samples of the original tumor and knowledge of DNA changes in that tumor to find those same changes in the blood. This new test has no need for original tumor samples and includes an analysis of changes in the copy number of chromosomes.
"It's an evolution of technologies we're developing for cancer diagnosis, and, by combining our knowledge, we can build better ways to detect disease," says Luis Diaz, M.D., an oncologist and director of the Swim Across America laboratory at Johns Hopkins.
Thanks to Johns Hopkins Medicine for this article.
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Barcelona's Andres Iniesta celebrates after scoring a goal against Levante during their la liga soccer match at the Ciutat Valencia stadium in Valencia, Spain, Sunday, Nov. 25, 2012. (AP Photo/ Alberto Saiz)
Barcelona's Andres Iniesta celebrates after scoring a goal against Levante during their la liga soccer match at the Ciutat Valencia stadium in Valencia, Spain, Sunday, Nov. 25, 2012. (AP Photo/ Alberto Saiz)
Barcelona's Lionel Messi from Argentina, right, is congratulated by teammate after scoring a goal against Levante during their la liga soccer match at the Ciutat Valencia stadium in Valencia, Spain, Sunday, Nov. 25, 2012.(AP Photo/ Alberto Saiz)
Barcelona's Lionel Messi from Argentina is tackled by Levante's Vicente Iborra during their la liga soccer match at the Ciutat de Valencia stadium in Valencia, Spain, Sunday, Nov. 25, 2012.(AP Photo/ Alberto Saiz)
Real Madrid's Cristiano Ronaldo from Portugal reacts against Betis during their La Liga soccer match at the Benito Villamarin stadium, in Seville, Spain on Saturday, Nov. 24, 2012. Betis won 1-0(AP Photo/Angel Fernandez)
SAO PAULO (AP) ? Lionel Messi, Cristiano Ronaldo and Andres Iniesta are the finalists for FIFA's world player of the year award.
They were picked from a list of 23 candidates for this year's Ballon d'Or, with Messi looking to become the first player to win the award four times. The Argentina and Barcelona playmaker won the award the last three years.
"I think they are perfect picks. There is no doubt these players are among the best," said former Brazil great Ronaldo, a three-time award winner. "Messi and Ronaldo are really the only ones with a chance of winning, that's how it's been recently."
The winner will be announced in Switzerland on Jan. 7. The only other players to have won the FIFA award three times are Ronaldo and former France great Zinedine Zidane.
The finalists for the women's world player award are five-time winner Marta and America duo Alex Morgan and Abby Wambach.
They led the United States to its third straight Olympic gold medal in London. Wambach made the shortlist last year, finishing third in the voting.
"Women's football was at its best this year," FIFA President Sepp Blatter said, noting the record crowds attending the matches at the London Games.
Spain coach Vicente Del Bosque, former Barcelona coach Pep Guardiola and Real Madrid coach Jose Mourinho were in the running for the world coach of the year award. The women's coach of the year award nominees are France's Bruno Bini, Japan's Norio Sasaki and former U.S. coach Pia Sundhage, who led the team to the gold at the 2012 Games.
The Puskas Award for the best goal of the year will be presented to Radamel Falcao, Neymar or Miroslav Stoch.
The 25-year-old Messi won his second Golden Boot award this year for scoring the most goals in Europe's domestic leagues last season. He has scored 82 goals this calendar year, putting him only three shy of Gerd Mueller's record.
Messi won last year's Ballon d'Or prize over Cristiano Ronaldo, who scored a team leading 46 goals last season for Real Madrid.
Cristiano Ronaldo ? the winner in 2008 ? was one of the six nominees from Real Madrid, along with Xabi Alonso, Karim Benzema, Iker Casillas, Mesut Oezil and Sergio Ramos. In addition to Messi and Iniesta, the 23-player list also included Barcelona players Xavi Hernandez, Gerard Pique and Sergio Busquets.
Iniesta finished second to Messi in the 2010 vote.
Seven Spain internationals made the 23-name list and all three in the shortlist play in the Spanish league.
"This shows how strong the football is in Spain, not only in the clubs but also the national team," FIFA secretary general Jerome Valcke said. "We have a very strong (Spanish) football system in place."
Manchester City striker Mario Balotelli and Brazil forward Neymar were also in the running. Manchester United striker Wayne Rooney was the only English player on the list, while United teammate Robin van Persie also was a candidate after being the Premier League's leading scorer last season for Arsenal.
Juventus veteran Gianluigi Buffon was among the three goalkeepers in the list, along with Casillas and Manuel Neuer of Bayern Munich.
Marta is looking for an unprecedented sixth award.
"It's a great honor to be in the running again," Marta said.
Neymar won the 2011 goal of the year award and is looking to retain the prize courtesy of his goal for Santos against Internacional on March 7, when he scored following a maze of dribbling from mid-field. Falcao is in the running for his overhead kick on May 19 in Atletico Madrid's game against America de Cali, while Stoch is in the final list for his superb hook shot from the edge of the box for Fenerbahce on March 3.
Voting is by national team coaches and captains, and journalists invited by co-organizer "France Football" magazine.
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As a real estate agent, it is best to be upfront with both the sellers and buyers of real estate. ?That includes taking photographs of the area and surrounding neighborhood to make sure the Buyer knows what they are getting into. ?When we have a real estate seller that has some ?issue? that most buyers are going to have a hard time overcoming ? we tell them to put it out there. ?Display that ?issue? in all of it?s glory. ?They?d be surprised as to how many buyers can then accept something they would not have been able to accept before because of it being hidden on purpose.
Photos make a difference when selling Santa Clarita real estate. When you make the decision to sell your home you will most likely choose a REALTOR to work with. Recommendations, a number of conversations, or perhaps a history of working with a certain real estate professional in your area will help you choose the person you want to list your home but perhaps you want to consider throwing photos in the mix as well. Have you noticed some great photo ads in your local paper or perhaps on a real estate website? Perhaps speaking with one of these companies can help you get the results that you are looking for.
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A video from Harvard's Wyss Institute explains how strands of DNA can be assembled into three-dimensional nanostructures like tiny Lego building blocks.
By Alan Boyle
Researchers at Harvard's Wyss Institute have coaxed single strands of DNA to fit together like Lego bricks and form scores of complex three-dimensional shapes, including a teeny-tiny space shuttle. The technique, described in this week's issue of the journal Science, adds a new dimension to molecular construction and should help open the way for nanoscale medical and electronic devices.
"This is a simple, versatile and robust method," the study's senior author, Peng Yin, said in a news release.
The method starts with synthetic strands of DNA that take in just 32 nucleotides, or molecular?bits of genetic code. These individual "bricks" are coded in a way that they fit together like Lego pegs and holes to form larger shapes of a specific design. A cube built up from 1,000 such bricks (10 by 10 by 10) measures just 25 nanometers in width. That's thousands of times smaller than the diameter of a single human hair.
The latest research builds upon work that the Wyss researchers detailed in May, which involved piecing together DNA strands to create two-dimensional tiles (including cute smiley faces). This time around, the strands were twisted in such a way that they could be interlocked, Lego-style. As any visitor to Legoland knows, such structures can get incredibly complex in the hands of a skilled builder.
Yin and his colleagues are still learning their building techniques. Fortunately, the bricks could be programmed to build themselves, with the aid of 3-D modeling software. Once the designs were set, the researchers synthesized strands with the right combinations of nucleotides ??adenosine, thymine, cytosine and guanine ? so that when they were mixed together in a solution, at least some of the bricks would form the desired design.
To demonstrate the method, 102 different 3-D shapes were created using a 1,000-brick template.
The Wyss researchers reported a wide variation in assembly success rate, or yield: Depending on the design, the yield ranged from 1 percent to 40 percent.?That's roughly in the same range as the success rate for another method for molecular assembly, known as DNA origami. The origami method requires more custom work to design the "staples" to hold the DNA structures together, while the Lego-style method can rely more easily on a standard toolbox of DNA bricks.
In the future, DNA origami and DNA brick-building may be used together, said Kurt Gothelf, director of the Center for DNA Nanotechnology at Aarhus University in Denmark. "It is likely that a combination of the two methods will pave the way for making even larger structures in higher yields," Gothelf wrote in a commentary for Science.
Researchers say complex nanostructures could be used as smart drug delivery devices inside the human body, or as the components for microscopic electronic or photonic devices. It may look as if scientists are just playing around with smiley faces and toy shuttles, but a few years from now, DNA bricks will be no laughing matter.
Update for 3:30 p.m. ET: Peng Yin put me in touch with the Wyss Institute's Yonggang Ke, the lead researcher for the study, for an email Q&A. Here's an edited transcript:
Cosmic Log: I'm trying to visualize the self-assembly process. The shapes are designed using software, and that yields a recipe list for different strands that are synthesized, and then the various ingredients are combined to assemble themselves into the desired shapes?
Ke:?"All the designs were done using software. First, a cubic '3-D canvas' model that contains 1,000 'voxels' was generated. [Each voxel represents an 8-base-pair connection between bricks.] Second, a list of a master collection of DNA strands (we ordered 4,455 strands) was generated based on the 3-D canvas. This master collection of strands covers all possibilities of shapes that can be designed from the 1,000-voxel 3-D canvas.Then we made 102 shapes using the software; each shape was designed by removing the unwanted voxels. At last, the software translates each shape to a recipe list of strands and sends the information to a robot for mixing the ingredients."
Q:?Do you have to select 'good' structures of Lego blocks from undesirable or misshapen Lego structures?
A:?"We didn't select the 'good' structures. That is why some structures' yields in the paper are so low. However, there are a few designed structures that failed self-assembly. They were mentioned in the supplementary material."
Q: I mentioned a couple of figures in the May report on your team's work with 2-D shapes: 12 to 17 percent yield, expected production of one desired shape per hour, $7,000 to synthesize a toolkit theoretically capable of producing 2 x 10^93 shapes. Do you have comparable figures for 3-D brick production?
A: "Yields of 3-D DNA-brick shapes were, on average, lower than 2-D DNA-brick shapes, but comparable to 3-D DNA origami structures. We saw yields varied from 1 percent to 40 percent, depending on the designs. The robot can make one 3-D shape per hour, which is similar to the pace for making 2-D shapes.?The master collection of 4,455 strands cost about $11,000, but we can produce 2^1000 (about 10^301) potential shapes. The much larger number of potential shapes is due to the higher resolution in our 3-D brick design." [The size of the voxels is smaller, with just 8 base pairs per voxel.]
Q:?Do you visualize combining the short-strand bricks into a completed structure, or building modular structures that are in turn built up into bigger structures (for example, that nanoscale space shuttle)? I assume this is where the combination of brick-building and origami might come in.
A:?"Combining multiple DNA-brick structures to form a larger structure via 'hierarchical assembly' is certainly on our mind. I think we will inevitably need to combine many different DNA assembly methods, including DNA brick and DNA origami."
Q: It sounds as if you expect bricks as well as origami to be used together for nanostructure synthesis. Is this a change from the way you expected the field to develop in earlier days, or did you always expect that the two approaches would end up being used in combination?
A: "The ultimate goal of the DNA-brick technique and DNA origami is the same: making larger, more complex, more stable DNA structures. The two methods are also intrinsically connected.
"I borrow a paragraph from our paper: 'DNA origami can also be related to the brick framework, in which half of the bricks are concatenated into a long scaffold. ... The successes of constructions that use only short strands (as in bricks) and those that include a long scaffold (as in origami) together suggest a full spectrum of motif possibilities with strands of diverse lengths: Longer strands may provide better structural support, and shorter ones may provide finer modularity and features; the eclectic use of both may lead to the most rapid progression toward greater complexity.'
"We certainly expect the two techniques will complement each other."
Q: Do you feel as if this establishes a sufficient toolkit for nanostructure building, or are there other steps or techniques that will still be required? Are you working on additional techniques?
??A:?"Far from sufficient. The DNA-brick technique is great, compared with a lot of existing methods. It is modular, simple, and can make many complex shapes that were not accessible before. However, it is still not quite enough for many reasons. First of all, the structures are still only nanometer-scale objects. It will be great if we can get them to micrometer or even millimeter sizes. Second, we need to increase the stability of structures for many applications. Third, we want to be able to transfer the structural information to a lot of other materials (e.g. metals, carbon, silicon, protein?) to achieve more functions."
Q: Any more insight into the mechanism that leads to self-assembly?
A: "Right now we don't have any new hypotheses. A more important task for now is to search a reliable assay for studying the assembly mechanism."
Q: Is there any way to put an estimated time frame on applications for DNA structure assembly, or describe the potential applications?
A:?"It is hard to predict a timetable. However, we believe we are really close to making high-profile real-world applications using DNA structures, considering the rapid growth of the field in recent years. Many papers have been published in the last couple of years, showing the potential for DNA structures in biophysical study, plasmonic devices, biosensoring, targeted delivery vehicle, etc.
Q: In May, we mentioned the potential for drug delivery or medical monitoring (for example, by nanomachines in the bloodstream). How does going from 2-D to 3-D change the outlook for applications? What are the big obstacles yet to be overcome?
A:?"For some applications, 2-D DNA structures would suffice. However, for applications like drug delivery, going 3-D makes all the difference. A delivery vehicle/machine has to be a 3-D object that contains protective shell, recognition sites, etc. Note that we are at early stage of developing nano medical devices using DNA structures. The biggest obstacles in the near future are perhaps how to increase the stability of DNA structures in complex biological environments and how to observe the behaviors of the DNA structures in vivo."?
Q: Anything to report on patenting these technologies or forming a venture to commercialize them?
A: "We have filed a provisional patent on the DNA-brick technique. We also have filed patents for other DNA techniques that we have invented in the past. We certainly expect that commercialization of these techniques will be a possibility in the future."
More about DNA assembly:
In addition to Yin and Ke, the authors of the Science paper, "Three-Dimensional Structures Self-Assembled From DNA Bricks," include Luvena L. Ong and William M. Shih. The work was supported by the Office of Naval Research, the Army Research Office, the National Institutes of Health, Wyss Institute and the National Science Foundation.
Alan Boyle is NBCNews.com's science editor. Connect with the Cosmic Log community by "liking" the log's?Facebook page, following?@b0yle on Twitter?and adding the?Cosmic Log page?to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other stories about science and space, sign up for the Tech & Science newsletter, delivered to your email in-box every weekday. You can also check out?"The Case for Pluto,"?my book about the controversial dwarf planet and the search for new worlds.
HELSINKI (Reuters) - BlackBerry maker Research In Motion Ltd (RIM) has lost a dispute over the use of Nokia Oyj patents, in a case which could halt the sale of RIM products if it does not reach a new royalties deal with the Finnish company.
The Swedish arbitrator ruled RIM was not entitled to make or sell mobile devices which can hook up to WiFi networks - using technology known in the trade as WLAN or wireless local access network systems - without first agreeing royalties with Nokia.
"RIM is liable to pay royalties and damages to Nokia for its ... sales of any subscriber terminals (handsets or tablets) ... compatible with the WLAN standard," the arbitrator said in the ruling, issued on November 6 but not publicized until Wednesday.
"RIM has not contested that it manufactures and sells products using WLAN in accordance with Nokia's WLAN patents," it added.
The decision is a boost for Nokia which is trying to increase its royalty income as its phone business slides, and the group said it had filed cases in the United States, Britain and Canada to enforce the arbitrator's ruling.
"This could have a significant financial impact to RIM, as all BlackBerry devices support WLAN," IDC analyst Francisco Jeronimo said.
A RIM spokesman declined comment.
A source close to RIM said the arbitration ruling was unlikely to have any immediate ramifications, as Nokia still has to fight a number of legal battles for the arbitration panel's ruling to be recognized in different countries.
But analysts said RIM would likely seek a royalty agreement with Nokia to avert any risk of sale bans.
"The arbitration decision is not appealable and the U.S. Court can be expected to enforce the judgment by issuing an injunction against RIM, which would effectively put RIM out of business," said Alexander Poltorak, chief executive of patent consultancy General Patent Corp.
"RIM has only one choice now - to license Nokia's patents," Poltorak said. "It should be a quick process. No substantive issue will be re-litigated. The U.S. court merely needs to enforce the verdict of the Swedish arbitration tribunal."
CONTRACT ROW
RIM, a smartphone pioneer, hopes new devices using BlackBerry 10 software, due early 2013, will rescue it from a prolonged slump in the face of competition from the likes of Apple Inc and Samsung Electronics Co Ltd.
"If a sales ban was imposed it would be a massive blow for RIM as it manages its transition to the new BlackBerry 10 software platform," said analyst Pete Cunningham at Canalys.
RIM promises its new devices will be faster than previous smartphones and will have a large catalogue of applications, which are crucial to the success of any new line of smartphones.
Shares in RIM were up 1.7 percent at $10.90 by 1146 ET on Nasdaq, while its Toronto-listed shares were up 11 Canadian cents at C$10.81.
Nokia said it signed a cross-license agreement with RIM covering cellular patents in 2003, a deal that was amended in 2008. RIM sought arbitration in March 2011 with the Stockholm Chamber of Commerce, arguing that license should be extended to cover WLAN patents.
Nokia, along with Ericsson and Qualcomm Inc, is among the leading patent holders in the wireless industry. Patent royalties generate annual revenue of about 500 million euros ($646 million) for Nokia.
Based on a Nortel patent sale and Google Inc's acquisition of Motorola Mobility, some analysts say Nokia's patent portfolio alone merits its current share price of around 2.50 euros.
However, the patent market has cooled since those deals were made and some industry experts say the "fair value" of patents in large portfolios is between $100,000 and $200,000, pricing Nokia's portfolio at up to 0.50 euros per share.
Nokia shares, which are heavily influenced by expectations of new smartphone model sales, were down 1 percent at 2.54 euros. The Wall Street Journal said the new Lumia 920 smartphone was worth considering but was heavy and thick.
($1=0.7733 euros)
(Additional reporting by Euan Rocha in Toronto; Editing by David Goodman and David Holmes)
LG, Verizon Stream 75 Popular TV Channels To LG Smart TV Platform
Premium LG Smart TV Application Offers Alternative to Set-top Box; Provides Access to 'Flex View' On-Demand Content
ENGLEWOOD CLIFFS, N.J., Nov. 28, 2012 /PRNewswire/ -- The powerful LG Smart TV platform from LG Electronics is the first to allow Verizon FiOS TV customers to enjoy 75 broadcast channels, serving as a set-top box alternative within the home. The new premium application on LG's 2012 Smart TVs and Blu-ray Disc players also delivers Verizon FiOS' on-demand content service, "Flex View.*"
"The expansive selection of channels from FiOS TV and on-demand content from Verizon's Flex View library further strengthens LG's Smart TV platform, giving consumers of all ages a virtually limitless amount of entertainment on TVs, Blu-ray players, PCs, even tablets and phones," said Samuel Chang, vice president, Smart TV and Innovation, LG Electronics USA, Inc.
"As we see more and more consumers adopting the multi-screen universe, LG continues to seek content and alliances that broaden our Smart TV offerings to provide the best experience on whichever device consumers choose to use," Chang said.
Verizon customers who subscribe to both FiOS TV and Internet service can access the application via the Smart World section on LG's Smart TV interface. Among the 75 channels are consumer favorites such as HBO, Food Network, NFL Network, TBS, VH1 and others, offering content for all age groups and preferences.
LG Smart TV owners also can access FiOS TV's Flex View, which offers more than 25,000 on-demand movies and show titles for purchase or rent on any Internet-connected device, whether home on a TV or PC, or on-the-go on a mobile device.
"Offering more FiOS channels on LG Smart TVs epitomizes Verizon's commitment to delivering the best in-home entertainment experience to our customers across the greatest number of viewing platforms," said Maitreyi Krishnaswamy, director of product services for Verizon. "We understand that consumers' content consumption habits are changing and consumers are engaging on many different platforms within the home. We're working with LG to make watching TV and interacting with it more interesting and enjoyable than ever before."
The FiOS TV application is easy to use with the LG Magic Remote, and now it's even simpler for FiOS subscribers to find the movie or TV show they want to watch. For the first time, Verizon's FiOS search on LG Smart TVs and Blu-ray players provide search results from a choice of 75 broadcast channels and Flex View content. In addition, parent-friendly features include parental PIN options to restrict mature content and a purchase PIN requirement for authorization of any rental and purchases of on-demand content through the application.
The premium Verizon FiOS application is available on all 2012 LG Smart TV series (LM9600, LM8600, LM7600, LM6700, LM6200, LS5700, PM9700, PM6700 and PM4700) and the BP620 LG connected Blu-ray player. The App is available in LG's Smart TV Smart World. For more information, please visit LG.com.
* Verizon FiOS TV and Internet subscriptions required and sold separately. Subscription to HBO, Cinemax and EPIX is also required to access those channels. Customers must be in range of a FiOS router to use Live Streaming Channels. Content and services vary by product and are subject to change without notice.
. Designs, features and specifications subject to change without notice. LG LED TVs are LCD TVs with LED backlighting. About LG Electronics USA
LG Electronics USA, Inc., based in Englewood Cliffs, N.J., is the North American subsidiary of LG Electronics, Inc., a $49 billion global force and technology leader in consumer electronics, home appliances and mobile communications. In the United States, LG Electronics sells a range of stylish and innovative home entertainment products, mobile phones, home appliances and business solutions, all under LG's "Life's Good" marketing theme. LG Electronics is a 2012 ENERGY STAR? Partner of the Year. For more information, please visit www.lg.com.
About Verizon
Verizon Communications Inc. (NYSE, Nasdaq: VZ), headquartered in New York, is a global leader in delivering broadband and other wireless and wireline communications services to consumer, business, government and wholesale customers. Verizon Wireless operates America's most reliable wireless network, with nearly 96 million retail customers nationwide.Verizon also provides converged communications, information and entertainment services over America's most advanced fiber-optic network, and delivers integrated business solutions to customers in more than 150 countries, including all of the Fortune 500.A Dow 30 company with $111 billion in 2011 revenues, Verizon employs a diverse workforce of 184,500.For more information, visit www.verizon.com.
VERIZON'S ONLINE NEWS CENTER: Verizon news releases, executive speeches and biographies, media contacts, high-quality video and images, and other information are available at Verizon's News Center on the World Wide Web at www.verizon.com/news. To receive news releases by email, visit the News Center and register for customized automatic delivery of Verizon news releases.
Almost 6 years after it was introduced, you still can't attach files to emails in iOS. While iOS 6 has introduced a method to attach photos and videos to in-progress emails, it suffers from poor discoverability, and only works with content from the Photos app. If you want to attach any other file to an email, it's a usability disaster.
How iOS file handling breaks down
Emailing, and including attachments in emails, is a common task and something that takes only a few seconds on the Mac with OS X. On an iPhone or iPad with iOS, it takes an annoying amount of time and causes an unreasonable amount of frustration. Here's some blog-theater by way of example:
"Hey, Rene, can you email me the dates for that trip?"
"Sure, Kevin." I grab my iPhone, open the Mail app, add Kevin as the recipient, add the subject "trip", paste in the dates, then--
"Could you also attach that outline for discussion topics?"
"Um..."
My only option now is to copy the contents of the email, trash it, go to the app I wrote the topics in, find the file, tap share, tap email, add Kevin again, add the subject again, paste in the dates again--
Shit. I deleted the app I wrote the topics in. A hotter, newer app came out and I started using that instead, and even though both use iCloud, neither has any idea the other exists so... I re-download the old app and pray the data is either still there, or magically comes back from the cloud.
"And those two PDF files about that thing?"
Double shit. Both those PDF files are in different PDF apps, one in a simple reader, the other one in an app that supports annotation. Now I have to send the discussion topics from one app, and each of the PDF files from their apps.
Now Kevin is laughing his ass of at me and asking me to tell him again how the iPhone is easy to use, and I want to punch things.
And the reason for all this is that Apple forgot a cardinal principle of design: unreasonable drives for simplicity sometimes lead to inane levels of complexity.
Right now, adding photo or video attachments to in-progress emails is done via the same pop-up menu originally introduced in IOS 3 for cut, copy, and paste. You have to tap the screen to get the popup, tap a tiny, obscure arrow button to get more options, and then tap to add the attachment.
An easy to find, easy to use attachment button would be simpler. It's a solution employed by third-party apps like Facebook, email clients like Gmail and Sparrow, and the official Twitter app and Tweetbot.
Some of these are more elegant than others, but all of them are more discoverable. Apple already uses a blue + button to add contacts. Something like that for attachments could work for attachments as well. I did a mockup just like that for a pre-iOS 6 article on higher hanging fruit, but I'll update it below.
Tapping the attachment button could bring up a Share Sheet that includes the Photos icon, so you could attach photos as normal, but also any other app icon that contains documents. Tapping an icon would bring up a list view of all the files associated with that app. It's a bit overwrought, but it fits with the existing iOS constructs, including the binding of files to apps, and has the advantage of familiarity-as-a-feature.
Depending on how many file-capable apps are installed, it could create a very dense Share Sheet. It also still requires the user remember which app contains which file.
That's why, for the last couple of years, I've been asking for a simple, flat document repository for iOS -- a Files app that works the same way as the Photos app (or Passbook app for that matter). A Files app for iOS would remove unnecessary cognitive load from users and solve a wide swathe of current usability problems with iOS, including email attachments.
With a document repository, any user file could be attached to any in-progress email, without the need for a Share Sheet, or for the user to remember app ownership. And it would do so in a way that's consistent with how iOS already works, increasing simplicity at the same time.
I had joined facebook from the very initial days of its existence, back in 2003. When it slowly became more widespread, I began reconnecting with many people from the past, people whom I had lost all contact with. I found friends from junior college, secondary school, even primary school on facebook. The world had been given a precious gift ? the gift of re-establishing lost relationships. I searched for Isha frequently on facebook in those early days, always hoping that I would find her again in a world so vast and densely-populated. I scrolled through countless Isha Doshi profiles, looking through the photos to see if any of them was the right Isha. It never was.
One day, a few weeks after arriving in Uganda, I was online, waiting for a large file to download at an excruciatingly slow rate, and with nothing better to do, I decided to waste some time on facebook. I messaged my close friends, looked through my newsfeed, and once more, I don?t know why, I decided to search for Isha. The last time I tried to find her was over 2 years ago, when I was bored with nothing better to do than waste large amounts of time on facebook. I didn?t seriously think I would find her, but lo-and-behold, there on my screen, the 2nd profile to pop up, was a face so familiar yet changed somehow. I clicked on her profile, and looked through her photos. I was stunned that I had finally found her. I sent a friend request and waited. A few days later, I noticed that she had accepted my request, but neither of us initiated any conversation. Perhaps we both remembered the last time we had tried to reconnect, and the awkward silence filling the gaps in our conversations. Perhaps neither of us knew what to say now, after so long. Who had she become? What was she like? Will there be any semblance of the old Isha that I knew and adored left in her?
I became preoccupied with other things, and all by forgot about this matter. Then, I received a facebook message from Isha. She had noticed that I had changed my current location to Kampala, Uganda. Her company that she set up with her husband has some major investments in Uganda, and her husband visits Uganda multiple times a year. She was astonished at the coincidence, and that prompted her first message to me. We sent a few messages back and forth, giving brief summaries of important events in our lives over the past decade (she got married and has 2 sons, I went to medical school and am becoming an obstetrician-gynecologist). Then, she told me that she was going to be in Nairobi for a few weeks, and asked me if I had time to travel there to meet up with her. And so it was with great excitement and trepidation that I boarded the Easy Coach bus for the 16-hour road trip from Kampala to Nairobi.
Online videos are one of the most effective ways to market your brand or your business to improve on profit. The reason that they are so effective is that people use the internet more for leisure and business purposes than other forms of media. Videos are able to grab people?s attention quite fast and easily. They are also able to convey a lot of information in a relatively short period of time.
You have to make a compelling video which will capture people?s attention in the midst of plenty of videos, photos and other types of competing messages. Some online video tips that you can use are that you must know what kind of information that you want to pass on. A cluttered video with too much information has the same effect of an online video that has too little information. Before you shoot the video, make a plan and know what you would like to say so that you can say effectively. Most people assume that just shooting an online video is good enough, but in the face of increasing forms of online advertising you want a video that will stand out. Pictures and music are great way to attract people?s attention but content is the most important part of the video.
For effective web video marketing, keep your messages short and sweet as opposed to one long video. If you cannot deliver your message in one video, break it up into short videos. This is because people will switch off the video if it is too long. Another important online video tip is to use a professional video production company because they will work with you to make your vision come to life. They will advise you on the best technical aspects of video production to use. Some of these aspects are things like sound, graphics, special effects and others. People respond more to professionally done vides as opposed to amateur ones. If you would like to attract new clients using online videos, you have to have your video done professionally.
A high quality video is a reflection of your business and products and sends out a message that you are worth their time and their money. If you can, it is best to produce at least three or more versions of your online video so you can change them up to keep people interested in your message. You should also make versions that are compatible with mobile devices such as phones, iPads and tables. This is to be able to reach as many people as possible, which is the purpose of using web video marketing.
A good high quality video that sends a message will not serve your purposes if you do not distribute so that people can see it. Use multiple channels such as YouTube, socil networks such as Twitter, Facebook and others, in addition to your website. One way to do this is to include brief branded introductions to B2B videos which will make people connect them to your business.
The art of researchPublic release date: 28-Nov-2012 [ | E-mail | Share ]
Contact: Clea Desjardins clea.desjardins@concordia.ca 514-848-2424 x5068 Concordia University
Concordia explores the grey zone between academic and artistic creation
Montreal, November 28, 2012
Concordia University researcher Louis Patrick Leroux is one scholar whose work often results in that type of outcome. A professor of creative writing and literature in Concordia's Department of English as well as its Dpartement d'tudes franaises, Leroux has spent years intimately involved in what is known as "research-creation," a process that fosters the development and renewal of knowledge through aesthetic, technical, instrumental or other innovations.
"There's a real need to bridge the gap between the creative and interpretive disciplines." Leroux says. "If we can make that connection, we can link the humanities more closely to arts communities and create an important dialogue between academic and artistic creation." He is now doing just that with his new book, Dialogues fantasques pour causeurs perdus, published by Prise de parole.
By blending dramatic dialogues and thoughts on the creative process, Leroux gives his readers a new take on what it means to create as both a passionate and academic exercise. Before being compiled into a book, Leroux's Dialogues were the fodder for a series of performative explorations, some theatrical, some filmed, others flirting with peformance art and installations at the Hexagram Concordia Centre for Research-Creation in Media Arts and Technologies.
Dialogues fantasques offers an artistic way to understand the creative process and, in so doing, helps unpack the mysteries behind research-creation. Equal parts academic treatise and work of fiction, it is constructed in a way that makes the reader part of the research-creation experience. Even the book's layout, designed by Concordia design professor Nathalie Dumont, invites the reader to think more about what it means to create and experience.
"There's a lot of fascinating work that goes on in universities around the world that never makes it into peer-reviewed journals," adds Leroux. He has been taking this message far and wide in recent months, thanks to lectures and keynote conferences on research creation at both Quebec City's Universit Laval and the Pontificia Universidad Catlica in Santiago, Chile. He has also explored these ideas as a Visiting Scholar at Duke University's Centre for the Study of Canada, as well as through his current position as scholar-in-residence at the National Circus School in Montreal.
Leroux's new book, Dialogues fantasques pour causeurs perdus, will be launched on Thursday, November 29 from 5 p.m. to 7 p.m. at Librairie Le Port de tte, 262 Mount Royal Avenue East.
###
Related Links:
Dialogues fantasques pour causeurs perdus http://resonance.hexagram.ca/dialogues-fantasques/
Resonance Lab http://resonance.hexagram.ca
Les ditions Prise de parole http://prisedeparole.ca/
HEXAGRAM http://hexagram.concordia.ca
Matralab http://matralab.hexagram.ca
Le dpartement d'tudes franaises l'Universit Concordia http://francais.concordia.ca/
Concordia's Department of English Literature http://english.concordia.ca/index.php
Louis Patrick Leroux's Research @ Concordia profile http://www.concordia.ca/explore/#!/profile/70/
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
The art of researchPublic release date: 28-Nov-2012 [ | E-mail | Share ]
Contact: Clea Desjardins clea.desjardins@concordia.ca 514-848-2424 x5068 Concordia University
Concordia explores the grey zone between academic and artistic creation
Montreal, November 28, 2012
Concordia University researcher Louis Patrick Leroux is one scholar whose work often results in that type of outcome. A professor of creative writing and literature in Concordia's Department of English as well as its Dpartement d'tudes franaises, Leroux has spent years intimately involved in what is known as "research-creation," a process that fosters the development and renewal of knowledge through aesthetic, technical, instrumental or other innovations.
"There's a real need to bridge the gap between the creative and interpretive disciplines." Leroux says. "If we can make that connection, we can link the humanities more closely to arts communities and create an important dialogue between academic and artistic creation." He is now doing just that with his new book, Dialogues fantasques pour causeurs perdus, published by Prise de parole.
By blending dramatic dialogues and thoughts on the creative process, Leroux gives his readers a new take on what it means to create as both a passionate and academic exercise. Before being compiled into a book, Leroux's Dialogues were the fodder for a series of performative explorations, some theatrical, some filmed, others flirting with peformance art and installations at the Hexagram Concordia Centre for Research-Creation in Media Arts and Technologies.
Dialogues fantasques offers an artistic way to understand the creative process and, in so doing, helps unpack the mysteries behind research-creation. Equal parts academic treatise and work of fiction, it is constructed in a way that makes the reader part of the research-creation experience. Even the book's layout, designed by Concordia design professor Nathalie Dumont, invites the reader to think more about what it means to create and experience.
"There's a lot of fascinating work that goes on in universities around the world that never makes it into peer-reviewed journals," adds Leroux. He has been taking this message far and wide in recent months, thanks to lectures and keynote conferences on research creation at both Quebec City's Universit Laval and the Pontificia Universidad Catlica in Santiago, Chile. He has also explored these ideas as a Visiting Scholar at Duke University's Centre for the Study of Canada, as well as through his current position as scholar-in-residence at the National Circus School in Montreal.
Leroux's new book, Dialogues fantasques pour causeurs perdus, will be launched on Thursday, November 29 from 5 p.m. to 7 p.m. at Librairie Le Port de tte, 262 Mount Royal Avenue East.
###
Related Links:
Dialogues fantasques pour causeurs perdus http://resonance.hexagram.ca/dialogues-fantasques/
Resonance Lab http://resonance.hexagram.ca
Les ditions Prise de parole http://prisedeparole.ca/
HEXAGRAM http://hexagram.concordia.ca
Matralab http://matralab.hexagram.ca
Le dpartement d'tudes franaises l'Universit Concordia http://francais.concordia.ca/
Concordia's Department of English Literature http://english.concordia.ca/index.php
Louis Patrick Leroux's Research @ Concordia profile http://www.concordia.ca/explore/#!/profile/70/
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
If you've pre-ordered a Verizon flavor of Samsung's Galaxy Note II, it's high time you check your email for a shipping confirmation, as we just received a notice of our own. With two-day shipping on the package carrying our smartphone behemoth, it's estimated to arrive on November 29th. Presumably, it'll be available at Big Red's brick-and-mortar establishments on that same day, but we've reached out to Verizon and Samsung for confirmation. In the meantime, you can peep inside your inboxes and let us know in the comments if your hulking handset is on its way as well.
Contact: Philippe Baveye baveyp@rpi.edu American Society of Agronomy
Imagine printing a 3-D object as easily as a typed document. Lose a button? Print one. Need a new coffee cup? Print one. While the reality of printing any object on demand may lie in the future, the technology necessary to do it has been available for decades. And soil scientists are now taking advantage of its possibilities.
In a paper published online this week in the Soil Science Society of America Journal, a team of researchers headed by Philippe Baveye explored the potential of manufacturing soil science equipment using 3-D printing. They found that the technology, also called "rapid manufacturing" or "stereolithography," has major benefits over traditional manufacturing methods, and they were able to successfully produce intricate pieces. Also, the ability to easily share the designs used by 3-D printers could allow for better replication of experiments and collaboration among soil scientists.
First developed in the 1980s, the process of 3-D printing begins with a computer-generated model [often a Computer Aided Design (CAD) image] that is "sliced" by a program to create very thin layers of the object. The printer then uses an extruder that lays down a material frequently a thermal plastic layer by layer, as defined by the computer program, to create the full 3-D object. This method is currently being used to build a variety of items, such as mobile phones, jewelry, and artificial limbs.
Baveye's team used the technology to create parts of a permeameter, a device used to measure the hydraulic conductivity of soils. Traditionally, this type of equipment is made using lathes and drills. However, those techniques are painstaking and time-consuming. Also, traditional methods cannot create intricate designs or incorporate certain features such as non-concentric structures. Moreover, once a product is made, researchers are resistant to making changes even if the piece would work better if modified.
Baveye and his colleagues found that by using a 3-D printer to create their design of the permeameter parts, they were able to avoid several of these problems of traditional equipment manufacturing. Many designs that used to be impossible to make, such as intricate conduits, can now be easily worked into the 3-D printing models. Also, once a piece is designed and even manufactured, changes to the product can be easily made in the computer model and printed anew.
Says Baveye, "Should anyone want permeameter columns with a narrower or larger diameter, designs can be scaled up or down in seconds, and a new piece can be printed without extra human labor."
By avoiding the painstaking and backbreaking work of traditional methods, 3-D printing has inadvertently leveled the playing field. While in the past few students and researchers were willing to use the drills and lathes, many more now look forward to the opportunity to create and print CAD drawings. This technology has opened doors to aspiring soil scientists that may have otherwise passed on the opportunity to create designs and equipment for their research.
An additional benefit of using 3-D printing, and one that Baveye believes could greatly impact soil science, is the ease with which designs can be shared among researchers. When equipment is made using traditional methods, detailed procedures and even blueprints have to be provided for replication of the experiment. Even then, there are often details that make it difficult for others to produce the same design. 3-D printing eliminates this hurdle.
"CAD files can be easily sent by email to colleagues anywhere in the world," explains Baveye. "That means experiments can be replicated easily, even if they involve complicated pieces of equipment."
While the benefits of 3-D printing are obvious, there are some limitations. The object design must consist of contiguous solid material, and the smallest features must be larger than the minimum resolution of the printer being used. Even with these constraints, however, 3-D printing offers a promising alternative to older manufacturing methods, and Baveye and his colleagues have no doubt that the technology will become a mainstream method.
"We expect that the evolution of 3-D printing will follow that of laser printers," says Baveye. "As the price of 3-D printers continues to fall, we expect that they are going to be more and more widely used in soil science laboratories and in many other disciplines."
###
The full article is available for no charge for 30 days following the date of this summary. View the abstract at https://dl.sciencesocieties.org/publications/sssaj/abstracts/0/0/sssaj2012.0196n.
Soil Science Society of America Journal, www.soils.org/publications/sssaj, is a peer-reviewed international journal published six times a year by the Soil Science Society of America. Its contents focus on research relating to physics; chemistry; biology and biochemistry; fertility and plant nutrition; genesis, morphology, and classification; water management and conservation; forest, range, and wildland soils; nutrient management and soil and plant analysis; mineralogy; and wetland soils.
The Soil Science Society of America (SSSA) is a progressive, international scientific society that fosters the transfer of knowledge and practices to sustain global soils. Based in Madison, WI, SSSA is the professional home for 6,000+ members dedicated to advancing the field of soil science. It provides information about soils in relation to crop production, environmental quality, ecosystem sustainability, bioremediation, waste management, recycling, and wise land use.
SSSA supports its members by providing quality research-based publications, educational programs, certifications, and science policy initiatives via a Washington, DC, office. Founded in 1936, SSSA proudly celebrated its 75th Anniversary in 2011. For more information, visit www.soils.org or follow @SSSA_soils on Twitter.
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?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Contact: Philippe Baveye baveyp@rpi.edu American Society of Agronomy
Imagine printing a 3-D object as easily as a typed document. Lose a button? Print one. Need a new coffee cup? Print one. While the reality of printing any object on demand may lie in the future, the technology necessary to do it has been available for decades. And soil scientists are now taking advantage of its possibilities.
In a paper published online this week in the Soil Science Society of America Journal, a team of researchers headed by Philippe Baveye explored the potential of manufacturing soil science equipment using 3-D printing. They found that the technology, also called "rapid manufacturing" or "stereolithography," has major benefits over traditional manufacturing methods, and they were able to successfully produce intricate pieces. Also, the ability to easily share the designs used by 3-D printers could allow for better replication of experiments and collaboration among soil scientists.
First developed in the 1980s, the process of 3-D printing begins with a computer-generated model [often a Computer Aided Design (CAD) image] that is "sliced" by a program to create very thin layers of the object. The printer then uses an extruder that lays down a material frequently a thermal plastic layer by layer, as defined by the computer program, to create the full 3-D object. This method is currently being used to build a variety of items, such as mobile phones, jewelry, and artificial limbs.
Baveye's team used the technology to create parts of a permeameter, a device used to measure the hydraulic conductivity of soils. Traditionally, this type of equipment is made using lathes and drills. However, those techniques are painstaking and time-consuming. Also, traditional methods cannot create intricate designs or incorporate certain features such as non-concentric structures. Moreover, once a product is made, researchers are resistant to making changes even if the piece would work better if modified.
Baveye and his colleagues found that by using a 3-D printer to create their design of the permeameter parts, they were able to avoid several of these problems of traditional equipment manufacturing. Many designs that used to be impossible to make, such as intricate conduits, can now be easily worked into the 3-D printing models. Also, once a piece is designed and even manufactured, changes to the product can be easily made in the computer model and printed anew.
Says Baveye, "Should anyone want permeameter columns with a narrower or larger diameter, designs can be scaled up or down in seconds, and a new piece can be printed without extra human labor."
By avoiding the painstaking and backbreaking work of traditional methods, 3-D printing has inadvertently leveled the playing field. While in the past few students and researchers were willing to use the drills and lathes, many more now look forward to the opportunity to create and print CAD drawings. This technology has opened doors to aspiring soil scientists that may have otherwise passed on the opportunity to create designs and equipment for their research.
An additional benefit of using 3-D printing, and one that Baveye believes could greatly impact soil science, is the ease with which designs can be shared among researchers. When equipment is made using traditional methods, detailed procedures and even blueprints have to be provided for replication of the experiment. Even then, there are often details that make it difficult for others to produce the same design. 3-D printing eliminates this hurdle.
"CAD files can be easily sent by email to colleagues anywhere in the world," explains Baveye. "That means experiments can be replicated easily, even if they involve complicated pieces of equipment."
While the benefits of 3-D printing are obvious, there are some limitations. The object design must consist of contiguous solid material, and the smallest features must be larger than the minimum resolution of the printer being used. Even with these constraints, however, 3-D printing offers a promising alternative to older manufacturing methods, and Baveye and his colleagues have no doubt that the technology will become a mainstream method.
"We expect that the evolution of 3-D printing will follow that of laser printers," says Baveye. "As the price of 3-D printers continues to fall, we expect that they are going to be more and more widely used in soil science laboratories and in many other disciplines."
###
The full article is available for no charge for 30 days following the date of this summary. View the abstract at https://dl.sciencesocieties.org/publications/sssaj/abstracts/0/0/sssaj2012.0196n.
Soil Science Society of America Journal, www.soils.org/publications/sssaj, is a peer-reviewed international journal published six times a year by the Soil Science Society of America. Its contents focus on research relating to physics; chemistry; biology and biochemistry; fertility and plant nutrition; genesis, morphology, and classification; water management and conservation; forest, range, and wildland soils; nutrient management and soil and plant analysis; mineralogy; and wetland soils.
The Soil Science Society of America (SSSA) is a progressive, international scientific society that fosters the transfer of knowledge and practices to sustain global soils. Based in Madison, WI, SSSA is the professional home for 6,000+ members dedicated to advancing the field of soil science. It provides information about soils in relation to crop production, environmental quality, ecosystem sustainability, bioremediation, waste management, recycling, and wise land use.
SSSA supports its members by providing quality research-based publications, educational programs, certifications, and science policy initiatives via a Washington, DC, office. Founded in 1936, SSSA proudly celebrated its 75th Anniversary in 2011. For more information, visit www.soils.org or follow @SSSA_soils on Twitter.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Online videos are one of the most effective ways to market your brand or your business to improve on profit. The reason that they are so effective is that people use the internet more for leisure and business purposes than other forms of media. Videos are able to grab people?s attention quite fast and easily. They are also able to convey a lot of information in a relatively short period of time.![[ Back to EurekAlert! ]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_tVIaZOyH1e3Pfg-lF4QJi2IQzBe_WL8otToZtx7mKxPux59eZzEdr80QDBzc-iWzLfN4ofdmqss4wXp4gYN9KZ_u9d9KrBImN6-vKal9o=s0-d){kind=small}
Public release date: 28-Nov-2012
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