From The Science Codex?..
Joint research between the University of Michigan and the Argentina-based National Council of Science and Technology (CONICET) has shed light on one of the most frustrating mysteries of weight loss ? why the weight inevitably comes back.
A novel animal model showed that the longer mice remained overweight, the more ?irreversible? obesity became, according to the new study that appeared online ahead of print Oct.24 in the Journal of Clinical Investigation.
Over time, the static, obese state of the mice reset the ?normal,? body weight set point to become permanently elevated, despite dieting that initially worked to shed pounds, authors say.
?Our model demonstrates that obesity is in part a self-perpetuating disorder and the results further emphasize the importance of early intervention in childhood to try to prevent the condition whose effects can last a lifetime,? says senior author Malcolm J. Low, M.D., Ph.D., professor of molecular and integrative physiology and internal medicine.
?Our new animal model will be useful in pinpointing the reasons why most adults find it exceedingly difficult to maintain meaningful weight loss from dieting and exercise alone.?
The lead author of the study was Viviana F. Bumaschny, M.D., assistant investigator of CONICET.
Obesity affects more than 500 million adults and 43 million children younger than age 5, while related illnesses are the leading preventable cause of death. Individuals who are overweight have a much higher risk of type 2 diabetes, hypertension, and cardiovascular diseases.
One of the major strengths of the research was a new model of obesity-programmed mice that allowed weight loss success to be tracked at different stages and ages by flipping a genetic switch that controls hunger.
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Source: http://www.lensaunders.com/wp/?p=5897
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